Chromatin remodeling factor lymphoid-specific helicase inhibits ferroptosis through lipid metabolic genes in lung cancer progression

作者：Jiang, Yiqun; He, Yuchen; Liu, Shuang^*; Tao, Yongguang^*

来源：Chinese Journal of Cancer, 2017, 36(1): 82.

DOI：10.1186/s40880-017-0248-x

• FACTOR LSH

<正>Ferroptosis,a novel mode of non-ap opto tic cell death,involves a metabolic dysfunction that results in the production of iron-dependent reactive oxygen species(ROS),an iron carrier protein(transferrin),intracellular metabolic process,and related regulators(e.g.,p53 protein).Previous studies have linked ferroptosis with oncogenic Ras[1],and p53 tumor suppressor positively regulates

• 出版日期2017-10-16
• 单位河北医科大学; 中南大学