Astrocyte elevated gene-1 expression in urothelial bladder carcinoma and its clinical significance

作者：Guo, Yongshun; Zhu, Tao; Zhuang, Guishan; Zhang, Shidong; Qi, Lei^*; Li, Wen; Zang, Yunjiang

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(12): 12779-12784.

• Bladder tumor
• cancer
• astrocyte elevated gene-1
• micro-vessel density

Objectives: To determine the expression of astrocyte elevated gene-1 (AEG-1) in urothelial bladder carcinoma and its clinical significance. Methods: AEG-1 and CD34 expressions in 95 cases of urothelial bladder carcinoma tissues and 10 cases of normal bladder peritumorial tissues were detected by immunohistochemical method. The relation between AEG-1 expression and clinical pathology features in patients with urothelial bladder carcinoma, as well as micro-angiogenesis and its prognosis significance were analyzed. Results: AEG-1 is not expressed in normal bladder mucous membrane tissues. Among 95 cases of urothelial bladder carcinoma tissues, 42 cases (44.2%) had positive expression of AEG-1. AEG-1 expression was positively related to tumor classification and periodization. AEG-1 expression was closely related to tumor micro-angiogenesis and the micro-vessel density of the positive group was evidently higher than that of the negative group. AEG-1 had no evident influence on tumor-free survival of patients with urothelial bladder carcinoma, but it is not an independent prognosis factor. Conclusions: In the urothelial bladder carcinoma tissues, AEG-1 expression increases and it is related to biological behavior of malignant tumor and tumor micro-angiogenesis. AEG-1 may be a novel molecular marker and potential therapeutic target for diagnosis and prognosis prediction of urothelial bladder carcinoma.

• 出版日期2016
• 单位中山大学; 潍坊市人民医院