Age, weight and decompression sickness in rats

作者：Buzzacott, Peter^*; Theron, Michael; Mazur, Aleksandra; Wang, Qiong; Lambrechts, Kate; Eftedal, Ingrid; Ardestani, Simin Berenji; Guerrero, Francois

来源：Archives of Physiology and Biochemistry, 2016, 122(2): 67-69.

DOI：10.3109/13813455.2016.1140787

• Decompression illness
• diving
• Long-Evans
• regression modeling

Objective: The aim of this study was to determine if, after controlling for weight, age is associated with decompression sickness (DCS) in rats. Methods: Following compression-decompression, male rats aged 11 weeks were observed for DCS. After two weeks recovery, surviving rats were re-dived using the same compression-decompression profile. Results: In this experiment, there was a clear difference between DCS outcome at ages 11 or 13 weeks in matched rats (p=0.002). Discussion: Even with weight included in the model, age was significantly associated with DCS (p=0.01), yet after removal of weight the association was much stronger (p=0.002). Conclusion: We believe that age is likely to be found associated with the probability of DCS in a larger dataset with a wider range of parameters, after accounting for the effect of weight.