Memory, plasticity, and sleep - a role for calcium permeable AMPA receptors?

作者：Shepherd Jason D^*

来源：Frontiers in Molecular Neuroscience, 2012, 5.

DOI：10.3389/fnmol.2012.00049

• calcium permeable AMPA receptors
• sleep
• memory
• homeostatic plasticity
• synaptic plasticity
• drug addiction
• metaplasticity
• fear conditioning

Experience shapes and molds the brain throughout life. These changes in neuronal circuits are produced by a myriad of molecular and cellular processes. Simplistically, circuits are modified through changes in neurotransmitter release or through neurotransmitter detection at synapses. The predominant neurotransmitter receptor in excitatory transmission, the AMPA-type glutamate receptor (AMPAR), is exquisitely sensitive to changes in experience and synaptic activity. These ion channels are usually impermeable to calcium, a property conferred by the GluA2 subunit. However, GluA2-lacking AMPARs are permeable to calcium and have recently been shown to play a unique role in synaptic function. In this review, I will describe new findings on the role of calcium permeable AMPARs (CP-AMPARs) in experience-dependent and synaptic plasticity. These studies suggest that CP-AMPARs play a prominent role in maintaining circuits in a labile state where further plasticity can occur, thus promoting metaplasticity. Moreover, the abnormal expression of CP-AMPARs has been implicated in drug addiction and memory disorders and thus may be a novel therapeutic target.

• 出版日期2012