Association of aldose reductase gene polymorphism (C-106T) in susceptibility of diabetic peripheral neuropathy among north Indian population

作者：Gupta Balram; Singh S K^*

来源：Journal of Diabetes and Its Complications, 2017, 31(7): 1085-1089.

DOI：10.1016/j.jdiacomp.2017.04.011

• Aldose reductase
• Type 2 diabetes mellitus
• Diabetic peripheral neuropathy
• Genetic polymorphism
• Genetic risk factor

Aim/Hypothesis: Polymorphism in aldose reductase (ALR) gene at nucleotide C(-106)T (rs759853) in the promoter region is associated with susceptibility to development of diabetic peripheral neuropathy. The aim of this study was to detect the association of the C (-106)T polymorphism of ALR gene and its frequency among patients with type 2 diabetes mellitus with and without peripheral neuropathy.
Methods: The study subjects were divided into three groups. Group I included 356 patients with diabetes having peripheral neuropathy. Group II included 294 patients with diabetes without peripheral neuropathy and group III included 181 healthy subjects. Genotyping of ALR C(-106)T SNPs was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing methods. The genetic risk among the groups was compared and tested by calculating odds ratio with 95% class interval.
Results: ALR 106TT genotype was significantly higher in group I compared to group II with an odds ratio of 2.12 (95% CI: 1.22-3.67; p< 0.01). Recessive model (CC+CT vs. TT), as well as T allele distribution also showed significant association tq develop neuropathy with relative risk of 1.97 (95% CI: 1.16-3.35; p < 0.01) and 1.36 (95% CI: 1.07-1.72; p= 0.01) respectively.
Conclusion/Interpretation: In conclusion, the ALR C-106T polymorphism was associated with higher risk of peripheral neuropathy in patients with type 2 diabetes mellitus.

• 出版日期2017-7
• 单位河北医科大学