AMBRAI is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway

作者：Akatsuka Hisako; Kuga Shuhei; Masuhara Kaori; Davaadorj Odontuya; Okada Chisa; Iida Yumi; Okada Yoshinori; Fukunishi Nahoko; Suzuki Takahiro; Hosomichi Kazuyoshi; Ohtsuka Masato; Tanaka Masafumi; Inoue Ituro; Kimura Minoru; Sato Takehito^*

来源：Biochemical and Biophysical Research Communications, 2017, 491(4): 1098-1104.

DOI：10.1016/j.bbrc.2017.08.019

• AMBRAI
• Autophagy
• T-cell receptor
• Mitochondria
• Metabolic reprogramming
• ATG7

Metabolic reprogramming contributes to dynamic alteration of cell functions and characteristics. In T cells, TCR-mediated signaling evokes metabolic reprogramming and autophagy. AMBRA1 is known to serve in the facilitation of autophagy and quality control of mitochondria, but the role of AMBRA1 in T cell metabolic alteration is unknown. Here, we show that AMBRA1, but not ATG7, plays a role in TCR-mediated control of glycolytic factors and mitochondrial mass, while both AMBRAI and ATG7 are required for autolysosome formation. Our results suggested that AMBRAI is a core factor that controls both autophagy and metabolic regulation.

• 出版日期2017-9-30