Association of the TNF-alpha+489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis

作者：Cui, K.; Ge, X. Y.; Ma, H. L.^*

来源：Genetics and Molecular Research, 2015, 14(2): 5210-5220.

DOI：10.4238/2015.May.18.12

• Chronic obstructive pulmonary disease
• Meta-analysis
• Tumor necrosis factor-alpha
• Polymorphism

The association between the TNF-alpha + 489 G/A polymorphism and chronic obstructive pulmonary disease (COPD) remains controversial because of small group size and varied design among different studies. In the present study, a meta-analysis was conducted to assess the association between the + 489 G/A polymorphism and COPD risk. A comprehensive search was conducted to identify articles that have reported an association between the TNF-alpha + 489 G/A polymorphism and COPD risk. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated under both dominant (AA+GA vs GG genotypes) and allele (A vs G) models. Heterogeneity was assessed, as well as publication bias. Nine articles with ten eligible studies were included in this analysis. Significant association between the + 489 G/A polymorphism and COPD was identified in Asians under the allele model (OR = 1.582, 95% CI = 1.035-2.419). However, no significant difference was found in the Caucasian groups. Strong evidence for between-study heterogeneity was identified under both models, and no publication bias was detected. Our results indicated a potential role of the A allele of the TNF-alpha + 489 G/A polymorphism in increasing COPD risk in Asians, but not in Caucasians. Additional studies will be necessary to verify this conclusion.

• 出版日期2015
• 单位锦州医科大学