Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes

作者：Fernandez Gabriela A; Vela Gurovic Maria S; Olivera Nelda L; Chopa Alicia B; Silbestri Gustavo F

来源：Journal of Inorganic Biochemistry, 2014, 135: 54-57.

DOI：10.1016/j.jinorgbio.2014.03.001

• Water-soluble Au(I)
• N-heterocyclic carbene
• Antibacterial

The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropyl-phenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coll. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3.

• 出版日期2014-6