Nonenhanced Extracranial Carotid MR Angiography Using Arterial Spin Labeling: Improved Performance With Pseudocontinuous Tagging

作者：Koktzoglou Ioannis^*; Gupta NavYash; Edelman Robert R

来源：Journal of Magnetic Resonance Imaging, 2011, 34(2): 384-394.

DOI：10.1002/jmri.22628

• carotid angiography
• arterial spin labeling
• pulsed ASL
• pseudocontinuous ASL
• MRA

Purpose: To compare pulsed arterial spin labeling (PASL) and pseudocontinuous arterial spin labeling (PCASL) for nonenhanced extracranial carotid MR angiography (MRA).
Materials and Methods: Parametric signal equations for PASL and PCASL MRA were formulated and compared. Volunteer imaging (n = 7) at 1.5 Tesla was performed to compare the methods over a broad range of repetition and labeling times. Empirical results were compared with theoretical predictions. The feasibility of the optimal method was investigated in patients (n = 2) with sonographically documented carotid artery disease.
Results: In volunteers, PCASL provided significantly improved signal than PASL (range: 32-255% improvement; P < 0.01), and better supported the use of long labeling times and short repetition times. Excellent agreement between theory and experiment was found (intraclass correlation coefficient = 0.966; P < 0.001). PCASL provided excellent depiction of the carotid arteries in initial patient studies.
Conclusion: Compared with pulsed tagging, pseudocontinuous tagging provides improved performance for nonenhanced extracranial carotid MRA and warrants further clinical investigation.

• 出版日期2011-8
• 单位西北大学