A New Purine Derivative from the Roots of Phyllanthus flexuosus

作者：Zhu, Guanlin; Wang, Hongying^*; Gan, Kunrong; Gao, Heng; Li, Wei^*

来源：Natural Product Communications, 2018, 13(1): 41-44.

DOI：10.1177/1934578x1801300113

• Euphorbiaceae
• Phyllanthus flexuosus
• Purine derivative
• Cytotoxicity
• Acetylcholinesterase inhibition

A new purine derivative, 1-methyl-3-isopentenylisoguanine (1), together with six known compounds (2-7), was isolated from the roots of Phyllanthus flexuosus. The newly isolated structure was established by means of extensive spectroscopic analysis and single-crystal X-ray diffraction experiment. All isolates were evaluated for their in vitro cytotoxicities against two human hepatocellular carcinoma cell lines (HepG2 and SMMC-7721) by CCK-8 assays. Among them, three cleistanthane diterpenes (2-4) exhibited different levels of cytotoxicities against these cells with IC50 values ranging from 27.34 to 53.28 mu M. Furthermore, acetylcholinesterase inhibitory effect for the new purine derivative was also assessed.

• 出版日期2018-1
• 单位天津理工大学