A general, flexible, ring closing metathesis (RCM) based strategy for accessing the fused furo[3,2-b]furanone moiety present in diverse bioactive natural products

作者：Lone Ali Mohd; Bhat Bilal Ahmad^*; Mehta Goverdhan

来源：Tetrahedron Letters, 2013, 54(41): 5619-5623.

DOI：10.1016/j.tetlet.2013.08.021

• Ring closing metathesis
• Furo[3,2-b]furanone
• Natural products
• Baylis-Hillman adducts
• Sterically encumbered

A simple and straightforward methodology of general utility to construct sterically encumbered furo[3,2-b]furanone scaffolds present in a diverse range of bioactive natural products is delineated. The methodology emanates from readily available Morita-Baylis-Hillman adducts and employs sequential ring closing metathesis and oxy-Michael addition cascade as the key steps.

• 出版日期2013-10-9