Clinical characteristics of Helicobacter heilmannii-versus Helicobacter pylori-associated gastritis in Chinese patients

作者：Zhang H J; Cui R L; Han Y J; Shang H R; Zhang Y; Jin Z^*

来源：World Chinese Journal of Digestology, 2013, 21(3): 244-249.

DOI：10.11569/wcjd.v21.i1.244

• Gastric carcinoma
• Gastritis
• Helicobacter heilmannii
• Helicobacter pylori
• Precancerous lesions

AIM: To compare the endoscopic and histopathological characteristics of Helicobacter heilmannii (H. heilmannii) versus Helicobacter pylori (H. pylori) associated gastritis in Chinese patients. METHODS: Gastric biopsy specimens from 53 559 consecutive patients treated at Peking University Third Hospital from January 2003 to January 2010 were reviewed retrospectively. All cases of chronic gastritis were evaluated based on the Updated Sydney System. Endoscopic and histopathological characteristics of cases with H. heilmannii infection were compared with those with H. pylori infection. RESULTS: There were 46 cases with H. heilmannii infection (0.1) and 18 326 cases with H. pylori infection (34.2). Compared to H. pylori associated gastritis, H. heilmannii-associated gastritis showed a lower bacterial density (P < 0.001), less severe mononuclear cell infiltration (P < 0.001) and neutrophil activity (P < 0.001), and endoscopic findings of H. heilmannii-associated gastritis were devoid of ulcer (P = 0.021). H. heilmannii density showed a significant correlation with neutrophil activity (P = 0.02), but not with chronic inflammation (P = 0.159). The percentages of patients with mucosal atrophy, intestinal metaplasia and intraepthelial neoplasia in the H. heilmannii-associated gastritis group were 23.9, 21.7 and 4.3, respectively, and there was no significant difference in the prevalence and degree of these precancerous lesions between the two groups. A case of signet-ring cell carcinoma concomitant with H. heilmannii infection was detected. CONCLUSION: H. heilmannii-associated gastritis is uncommon and milder than H. pylori associated gastritis. The observation that there were no significant differences between two groups in the prevalence and degree of mucosal atrophy, intestinal metaplasia and intraepthelial neoplasia suggests that H. heilmannii may be partly responsible for malignant-associated lesions just as H. pylori does. In addition, one case of signet-ring cell carcinoma concomitant with H. heilmannii infection was noted.

• 出版日期2013
• 单位北京大学