Aggregation of Urinary Microcrystallines with Different Sizes

作者:Yao Xiu-Qiong*; He Jie-Yu; Yang Jin; Hou Shan-Hua; Ouyang Jian-Ming
来源:Journal of Inorganic Materials, 2012, 27(4): 343-347.
DOI:10.3724/SP.J.1077.2012.00343

摘要

Changes of average size ((d) over bar), autocorrelation curve, aggregation state and stability of urinary crystallites in urine samples of calcium oxalate (CaOxa) stone patients and healthy controls with placement time were comparatively studied using transmission electron microscopy (TEM) and nanoparticle size analyzer. The urine samples were filtrated by microporous membrane with a pore size of 0.22, 0.45, 1.2 and 3 mu m respectively. With the increase of placement time from 0 to 4 h, the (d) over bar values of the crystallites in various filtrated urine of patients increased rapidly. The amplification of (d) over bar (Delta(d) over bar) was 1439, 1557, 1534 and 1051 nm, respectively, when the placement time was up to 4 h. However, the Delta(d) over bar of the urine crystallites of the controls was relatively small, which was only 474, 511, 567 and 433 nm, respectively. The urinary crystallites of the patients had rapid and large agglomeration and poor stability compared with those of the controls. The urinary crystallites of small size agglomerated more easily than those of large size. The results show that the rapid agglomeration of urine crystallites may play an important role in the formation of CaOxa stones.

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