Magnesium sulfate ameliorates maternal and fetal inflammation in a rat model of maternal infection

作者：Tam Hima B Tam^*; Dowling Oonagh; Xue Xiangying; Lewis Dawnette; Rochelson Burton; Metz Christine N

来源：American Journal of Obstetrics and Gynecology, 2011, 204(4): 364.e1.

DOI：10.1016/j.ajog.2010.11.006

• chemokines
• cytokines
• fetal brain damage
• GRO-KC
• magnesium sulfate
• maternal infection
• MCP-1
• neuroprotection
• preterm labor

OBJECTIVE: Magnesium sulfate is proposed to have neuroprotective effects in the offspring. We examined the effects of maternal magnesium sulfate administration on maternal and fetal inflammatory responses in a rat model of maternal infection.
STUDY DESIGN: Pregnant rats were injected with saline, Gram-negative bacterial endotoxin lipopolysaccharide or lipopolysaccharide with magnesium sulfate (pre- and/or after lipopolysaccharide) to mimic infection. Maternal blood, amniotic fluid, fetal blood, and fetal brains were collected 4 hours after lipopolysaccharide and assayed for tumor necrosis factor, interleukin-6, monocyte chemoattractant protein-1, and growth-related oncogene-KC. In addition, the effect of magnesium sulfate on cytokine production by an astrocytoma cell line was assessed.
RESULTS: Lipopolysaccharide administration induced tumor necrosis factor, interleukin-6, monocyte chemoattractant protein-1, and growth-related oncogene-KC expression in maternal and fetal compartments. Maternal magnesium sulfate treatment significantly attenuated lipopolysaccharide-induced multiple proinflammatory mediator levels in maternal and fetal compartments.
CONCLUSION: Antenatal magnesium sulfate administration significantly ameliorated maternal, fetal, and gestational tissue-associated inflammatory responses in an experimental model of maternal infection.

• 出版日期2011-4
• 单位河北医科大学