Subthalamic deep brain stimulation for the treatment of Parkinson disease

作者：Mandat Tomasz^*; Tykocki Tomasz; Koziara Henryk; Koziorowski Dariusz; Brodacki Bogdan; Rola Rafat; Bonicki Wieslaw; Nauman Pawel

来源：Neurologia i Neurochirurgia Polska, 2011, 45(1): 32-36.

DOI：10.1016/s0028-3843(14)60057-8

• Parkinson disease
• deep brain stimulation
• subthalamic nucleus

Background and purpose: The role of subthalamic nucleus deep brain stimulation (STN DBS) in the treatment of Parkinson disease (PD) is well established. The authors present a group of patients diagnosed with PD who were treated with STN DBS.
Material and methods: Between 2008 and 2009, 32 female and 34 male patients with PD were treated with STN DBS. Mean age at implantation was 57 +/- 12 years. PD lasted from 6 to 21 years (mean 10 years). Patients were qualified for the surgery according to the CAPSIT-PD criteria. The STN was identified with direct and indirect methods. Macrostimulation and microrecording for STN identification were used in all cases. A unilateral STN DBS system was implanted in two cases and bilateral implantation was performed among rest of the group. Outcome was assessed six months after implantation.
Results: The mean reduction of UPDRS III score among SI patients who underwent follow-up was 45% (5-89%). Reduction of levodopa consumption varied from 15 to 100%. Infection forced the authors to remove the DBS system in one case four months after implantation. Skin erosion above the internal pulse generator was noted in four cases.
Conclusions: Cardinal symptoms of Parkinson's disease can be safely and effectively treated with STN DBS in selected group of patients.

• 出版日期2011-2