A genome-wide survey reveals a deletion polymorphism associated with resistance to gastrointestinal nematodes in Angus cattle

作者：Xu Lingyang; Hon Yali; Bickhart Derek M; Song Jiuzhou; Van Tassell Curtis P; Sonstegard Tad S; Liu George E^*

来源：Functional & Integrative Genomics, 2014, 14(2): 333-339.

DOI：10.1007/s10142-014-0371-6

• Copy number variation (CNV)
• Gastrointestinal nematodes
• Association

Gastrointestinal (GI) nematode infections are a worldwide threat to human health and animal production. In this study, we performed a genome-wide association study between copy number variations (CNVs) and resistance to GI nematodes in an Angus cattle population. Using a linear regression analysis, we identified one deletion CNV which reaches genome-wide significance after Bonferroni correction. With multiple mapped human olfactory receptor genes but no annotated bovine genes in the region, this significantly associated CNV displays high population frequencies (58.26 %) with a length of 104.8 kb on chr7. We further investigated the linkage disequilibrium (LD) relationships between this CNV and its nearby single nucleotide polymorphisms (SNPs) and genes. The underlining haplotype blocks contain immune-related genes such as ZNF496 and NLRP3. As this CNV co-segregates with linked SNPs and associated genes, we suspect that it could contribute to the detected variations in gene expression and thus differences in host parasite resistance.

• 出版日期2014-6
• 单位中国科学院北京基因组研究所