Downregulation of miR-16 promotes growth and motility by targeting HDGF in non-small cell lung cancer cells

作者：Ke Yang; Zhao Weiyong; Xiong Jie; Cao Rubo^*

来源：FEBS LETTERS, 2013, 587(18): 3153-3157.

DOI：10.1016/j.febslet.2013.08.010

• miR-16
• Non-small cell lung cancer
• HDGF
• Growth
• Migration
• Invasion

MicroRNAs play important roles in the development and progression of non-small cell lung cancer (NSCLC). miR-16 functions as a tumor-suppressor and is inhibited in several malignancies. Herein, we validated that miR-16 is downregulated in NSCLC tissue samples and cell lines. Ectopic expression of miR-16 significantly inhibited cell proliferation and colony formation. Moreover, miR-16 suppressed cell migration and invasion in NSCLC cells. Hepatoma-derived growth factor (HDGF) was found to be a direct target of miR-16 in NSCLC cell lines. Rescue experiments showed that the suppressive effect of miR-16 on cell proliferation, colony formation, migration, and invasion is partially mediated by inhibiting HDGF expression. This study indicates that miR-16 might be associated with NSCLC progression, and suggests an essential role for miR-16 in NSCLC.

• 出版日期2013-9-17
• 单位南京医科大学; 华中科技大学