A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides

作者：Vincetti Paolo; Brianza Anna; Scalacci Nicolo; Costantino Gabriele; Castagnolo Daniele; Radi Marco^*

来源：Tetrahedron Letters, 2016, 57(13): 1464-1467.

DOI：10.1016/j.tetlet.2016.02.068

• Multicomponent reaction
• Benzofuran
• Microwave
• Combinatorial chemistry

A fast, versatile and practical microwave-assisted multicomponent protocol for the synthesis of substituted benzofuran-2-carboxamides has been developed. The present method proved to be effective on a series of commercially available amines, 2'-hydroxyacetophenones, aldehydes, and benzonitriles and could be exploited in drug-discovery campaigns for the rapid identification of biologically active hit compounds.

• 出版日期2016-3-30