No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barre Syndrome in a Brazilian population

作者：Dourado Junior Mario Emilio; Ferreira Leonardo Capistrano; Freire Neto Francisco Paulo; Jeronimo Selma M B^*

来源：Journal of Neuroimmunology, 2016, 298: 160-164.

DOI：10.1016/j.jneuroim.2016.07.020

• Guillain-Barre Syndrome
• FCGR
• Polymorphism
• Genetics

The pathogenesis of Guillain-Barre Syndrome (GBS) is not entirely understood, but includes infection-induced aberrant immune responses. Genetic polymorphisms in Fc gamma receptor genes (FCGR) have been associated with GBS. We assessed whether polymorphisms rs1801274 in FCGR2A and rs396991 in FCGR3A were associated with GBS in a Brazilian population. We genotyped 141 GBS cases and 364 healthy controls from Brazil for both polymorphisms. The FCGR genotypes and alleles frequencies did not differ significantly between GBS and controls. In addition, there was no genetic association with either severity or clinical outcomes. We conclude that these FCGR polymorphisms are not associated with susceptibility to Guillain-Barre Syndrome in this Brazilian population.

• 出版日期2016-9-15