Anti-CD20 monoclonal antibodies: historical and future perspectives

作者:Lim Sean H; Beers Stephen A; French Ruth R; Johnson Peter W M; Glennie Martin J; Cragg Mark S*
来源:Haematologica-The Hematology Journal, 2010, 95(1): 135-143.
DOI:10.3324/haematol.2008.001628

摘要

Antibodies to CD20 have confirmed the hypothesis that monoclonal reagents can be given in vivo to alleviate human diseases. The targeting of CD20 on normal, malignant and auto-immune B-lymphocytes by rituximab has demonstrated substantial benefits for patients with a variety of B-cell lymphomas, as well as some with autoimmune disorders. There has been a notable increase in the survival rates from B-cell lymphoma in the decade since anti-CD20 therapy was introduced.

  • 出版日期2010-1