Actin-related proteins in the nucleus: life beyond chromatin remodelers

作者：Dion Vincent; Shimada Kenji; Gasser Susan M^*

来源：Current Opinion in Cell Biology, 2010, 22(3): 383-391.

DOI：10.1016/j.ceb.2010.02.006

Since their discovery in the mid-1990s, nuclear actin-related proteins (ARPs) have gained attention for their roles as structural components of ATP-dependent chromatin-remodeling complexes. These remodelers can move nucleosomes along the DNA, evict them from chromatin, and exchange histone variants to alter chromatin states locally. Chromatin-remodeling facilitates DNA-templated processes such as transcription regulation, DNA replication, and repair. Consistent with a role for ARPs in shaping chromatin structure, recent genetic studies show that they affect developmental and cell-type specific transcriptional programming. Here, we focus on recent results that suggest a specific contribution of ARPs to long-range interactions in the nucleus, and review evidence indicating that some ARPs may act independently of chromatin-remodeling machines.

• 出版日期2010-6