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摘要
Objectives: To evaluate the association between red cell distribution width (RDW) and the prevalence of hyperuricaemia (HU). Methods: A total of 125134 subjects (68540 men and 56594 women) were included in this study. The unadjusted association between RDW and HU was assessed by the Chi-square trend test. A multi-variable logistic analysis model was applied to test the proposed association. Results: The prevalence of HU in the total subjects was 15.4% (22.2% for male, 6.6% for female). The Chi-square trend test suggested a significant association between elevated RDW and the prevalence of HU (P < 0.01) in the male population, but not in the female. The multivariable-adjusted model indicated that the prevalence of HU increased by 22% in the male subjects with the RDW ranged from 15.6%-41.4% (95th-97.5th percentile interval) and increased by 12% in the male subjects with the RDW > 41.4% (higher than 97.5th percentiles), when compared with the male subjects with the RDW < 15.7% (lower than 95th percentiles); P for trend was 0.02. For the female subjects, both the unadjusted result (P = 0.74) and the multivariable logistic regression showed that there was no significant association between elevated RDW and the prevalence of HU. Sensitivity analysis was conducted after excluding abnormal serum creatinine or limiting middle aged and old subjects, the results were similar for males and females. Conclusion: Elevated RDW was associated with HU in the male population, but not in the female. Males with the RDW higher than the normal range may be subjects with a higher risk of HU.
- 出版日期2016
- 单位中南大学
