科研之友
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摘要
A concise synthesis of rhodanthpyrone A and B was accomplished via a Suzuki coupling reaction. To find the conditions appropriate to install hydroxyphenyl moieties to the a-pyrone skeleton, a model study was conducted using commercially available boronic acids. It was revealed that the hydroxy moiety of the phenylboronic acids should be concealed when reacted with labile 4-tosyl alpha-pyrone. Consequently, rhodanthpyrone A and B could be synthesized in high yields by Suzuki reaction using TIPS-protected arylboronic acids. This procedure provided a concise and versatile route for the synthesis of rhodanthpyrones and their 4-aryl substituted alpha-pyrone analogs.
- 出版日期2017-1
