A systematic review and economic evaluation of diagnostic strategies for Lynch syndrome

作者:Snowsill Tristan*; Huxley Nicola; Hoyle Martin; Jones Hughes Tracey; Coelho Helen; Cooper Chris; Frayling Ian; Hyde Chris
来源:Health Technology Assessment, 2014, 18(58): 1-+.
DOI:10.3310/hta18580

摘要

Lynch syndrome is inherited as an autosomal dominant disorder, whereby if one parent has the disease, there is a 50% chance that each of his or her children will inherit it. It is characterised by an increased risk of CRC and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain and skin among others, with the lifetime cancer risk highest for CRC (Table 1).