Mutator phenotypes due to DNA replication infidelity

作者：Arana Mercedes E; Kunkel Thomas A^*

来源：Seminars in Cancer Biology, 2010, 20(5): 304-311.

DOI：10.1016/j.semcancer.2010.10.003

• Fidelity
• DNA polymerase
• DNA replication
• Mutator phenotypes
• Microsatellite instability

This article considers the fidelity of DNA replication performed by eukaryotic DNA polymerases involved in replicating the nuclear genome. DNA replication fidelity can vary widely depending on the DNA polymerase, the composition of the error, the flanking sequence, the presence of DNA damage and the ability to correct errors. As a consequence, defects in processes that determine DNA replication fidelity can confer strong mutator phenotypes whose specificity can help determine the molecular nature of the defect. Published by Elsevier Ltd.

• 出版日期2010-10