A Prospective Multicenter Pilot Study of the Safety and Efficacy of Microfocused Ultrasound With Visualization for Improving Lines and Wrinkles of the Decollete

作者：Fabi Sabrina G^*; Goldman Mitchel P; Dayan Steven H; Gold Michael H; Kilmer Suzanne L; Hornfeldt Carl S

来源：Dermatologic Surgery, 2015, 41(3): 327-335.

DOI：10.1097/DSS.0000000000000322

BACKGROUND A previous pilot study demonstrated microfocused ultrasound with visualization (MFU-V) to lift and tighten the decollete produced significant and durable aesthetic improvements.
OBJECTIVE To further evaluate the safety and effectiveness of MFU-V for improving lines and wrinkles of the decollete in a larger patient population.
MATERIALS AND METHODS Healthy women with moderate-to-severe decollete skin lines and wrinkles were enrolled. After obtaining digital images, MFU-V was administered using 3 transducers emitting ultrasound at frequencies of 4 MHz and a focal depth of 4.5 mm, 7 MHz/3.0 mm, and 10 MHz/1.5 mm. During the procedure, 280 lines of discrete thermal coagulative points 25 mm long and 2 to 3 mm apart were applied to the treatment area. Additional imaging for masked assessments and live assessments were completed at 90 and 180 days.
RESULTS Among the evaluable subjects, 77 (66.4%) demonstrated aesthetic improvement at 180 days based on blinded assessments. Approximately, 75% and 65% of treated subjects demonstrated some degree of improvement at 90 and 180 days, respectively, and most were satisfied with treatment outcomes. Adverse events were generally mild.
CONCLUSION A single MFU-V treatment provided significant aesthetic improvement for moderate-to-severe decollete lines and wrinkles for at least the 180-day duration of the study.

• 出版日期2015-3