Mitochondrial DNA variations associated with recurrent pregnancy loss among Indian women

作者：Vanniarajan Ayyasamy; Govindaraj Periyasamy; Carlus S Justin; Aruna Meka; Aruna P; Kumar Ajay; Jayakar Richard Issac; Lionel Anath C; Gupta Sandeep; Rao Lakshmi; Gupta Nalini J; Chakravarthy Baidyanath; Deenadayal Mamatha; Selvaraj Kamala; Andal Sadaranga; Reddy B Mohan; Singh Lalji; Thangaraj Kumarasamy^*

来源：Mitochondrion, 2011, 11(3): 450-456.

DOI：10.1016/j.mito.2011.01.002

• Recurrent pregnancy loss
• mtDNA
• Haplogroup

Several genetic factors have been found to be associated with recurrent pregnancy loss (RPL). However, not many attempts have been made to associate the mitochondrial DNA (mtDNA) variations with RPL Therefore, we have analyzed the complete mtDNA of 100 women with RPL and 12 aborted fetal tissues. Our analysis revealed a total of 681 variations, most of which were in NADH Dehydrogenase (ND) genes that encode mitochondrial enzyme Complex I. Presence of T4216C variation

• 出版日期2011-5