Acute Promyelocytic Leukemia Following Chemotherapy for EBV-Associated Hemophagocytic Lymphohistiocytosis

作者：Sathiyamoorthy Srividya; Shad Aziza; Ozdemirli Metin^*

来源：Pediatric Blood and Cancer, 2011, 56(5): 850-852.

DOI：10.1002/pbc.22718

• EBV
• hemophagocytosis
• leukemia
• promyelocytic
• secondary
• therapy-related

We report a case of chemotherapy-related acute promyelocytic leukemia (APL) following therapy with VP-16/etoposide for EBV-associated hemophagocytic lymphohistiocytosis (HLH). A 17-month-old male presented with fever and lymphadenopathy. Bone marrow and liver biopsies showed hemophagocytosis. He responded well to chemotherapy including dexamethasone, VP16/etoposide, and cyclosporine. One and a half year later, he developed fever and pancytopenia. Clinical work-up revealed APL with t(15;17)(q22;q12); PML-RAR alpha translocation. He underwent chemotherapy for APL and is in remission 8 years after diagnosis. Alternative non-leukemogenic agents to effectively treat HLH would be desirable. Pediatr Blood Cancer. 2011;56:850-852.

• 出版日期2011-5