A comparison of two different continuous theta burst stimulation paradigms applied to the human primary motor cortex

作者：Goldsworthy Mitchell R; Pitcher Julia B; Ridding Michael C^*

来源：Clinical Neurophysiology, 2012, 123(11): 2256-2263.

DOI：10.1016/j.clinph.2012.05.001

• Transcranial magnetic stimulation
• Theta burst stimulation
• cTBS
• Motor cortex
• Plasticity
• Human

Objective: The application of repetitive transcranial magnetic stimulation (rTMS) in bursts at theta frequencies (TBS) may produce lasting neuroplastic changes in the human cortex. However, there exists high variability in subjects%26apos; responses, possibly due to non-optimal stimulation characteristics. Here we compare the efficacy of two variations of continuous TBS (cTBS) for producing neuroplastic change in the human primary motor cortex (M1). %26lt;br%26gt;Methods: The two cTBS paradigms were: (1) standard cTBS (cTBS(std)) (three stimuli at 50 Hz, repeated at 5 Hz), and (2) modified cTBS (cTBS(mod)) (three stimuli at 30 Hz, repeated at 6 Hz with intensity). Motor evoked potentials (MEPs) were recorded from the right first dorsal interosseous muscle before, as well as at 0, 5, 10, 20 and 30 min following each paradigm. %26lt;br%26gt;Results: Both cTBS(std) (P = 0.05) and cTBS(mod) (P %26lt; 0.0001) induced a suppression of MEP amplitudes. However, MEP suppression following cTBS(mod) was greater (ANOVA(RM); P = 0.02). Experiments using magnetic brain-stem stimulation provided evidence that cTBS(mod) induced MEP suppression through cortical mechanisms. %26lt;br%26gt;Conclusions: The neuroplastic response of the human M1 to cTBS is highly dependent on the stimulation parameters employed. %26lt;br%26gt;Significance: These findings may have significant implications for the clinical application of cTBS paradigms.

• 出版日期2012-11