Antibodies to a Novel Leptospiral Protein, LruC, in the Eye Fluids and Sera of Horses with Leptospira-Associated Uveitis

作者:Verma Ashutosh*; Matsunaga James; Artiushin Sergey; Pinne Marija; Houwers Dirk J; Haake David A; Stevenson Brian; Timoney John F
来源:Clinical and Vaccine Immunology, 2012, 19(3): 452-456.
DOI:10.1128/CVI.05524-11

摘要

Screening of an expression library of Leptospira interrogans with eye fluids from uveitic horses resulted in identification of a novel protein, LruC. LruC is located in the inner leaflet of the leptospiral outer membrane, and an lruC gene was detected in all tested pathogenic L. interrogans strains. LruC-specific antibody levels were significantly higher in eye fluids and sera of uveitic horses than healthy horses. These findings suggest that LruC may play a role in equine leptospiral uveitis.

  • 出版日期2012-3