Chromatin yo-yo: expansion and condensation during DNA repair

作者：Li Mischa L; Yuan Gang; Greenberg Roger A^*

来源：Trends in Cell Biology, 2014, 24(11): 616-618.

DOI：10.1016/j.tcb.2014.09.004

• chromatin
• DNA repair
• homologous recombination

DNA double-strand breaks are repaired by nonhomologous end-joining (NHEJ) and homologous recombination (HR). Disrupting the balance between these pathways results in toxic chromosomal rearrangements. Several recent studies are revealing that dynamic changes in chromatin conformation can regulate DNA repair pathway choice both spatially and temporally.

• 出版日期2014-11