Amaryllidaceae alkaloids from the bulbs of Lycoris radiata with cytotoxic and anti-inflammatory activities

作者：Liu, Zhi-Ming; Huang, Xiao-Yun; Cui, Mao-Rong; Zhang, Xiao-De; Chen, Zhao; Yang, Ben-Shou; Zhao, Xiao-Kun^*

来源：Fitoterapia, 2015, 101: 188-193.

DOI：10.1016/j.fitote.2015.01.003

• Lycoris radiata
• Amaryllidaceae
• Alkaloids
• Cytotcoxicity
• Anti-inflammatory activity

Four new Amaryllidaceae alkaloids, (+)-1-hydroxy-ungeremine (1), (+)-6 beta-acetyl-8-hydroxy-9-methoxy-crinamine (2), (+)-2-hydroxy-8-demethyl-homolycorine-alpha-N-oxide (3), (+)-N-methoxylcarbonyl-2-demethyl-isocorydione (4), together with two known compounds, (+)-6 beta-acetyl-crinamine (5) and 8-demethyl-homolycorine-alpha-N-oxide (6) were isolated from the ethanol extract of the bulbs of Lycoris radiata. Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (H-1-H-1 COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. All the isolated alkaloids were in vitro evaluated for their cytotoxic activities against eight tumor cell lines (BEN-MEN-1, CCF-STTG1, CHG-5, SHG-44, U251, BGC-823, HepG2 and SK-OV-3) and anti-inflammatory activities against Cox-1 and Cox-2. As a result, alkaloids 1 and 4 exhibited significant cytotoxic activities against all tested tumor cell lines except against BEN-MEN-1. Additionally, alkaloids 1 and 4 possessed selective inhibition of Cox-2 comparable with the standard drug NS-398 (>90%).

• 出版日期2015-3
• 单位中南大学