Design, Synthesis and Antiviral Potential of 14-Aryl/Heteroaryl-14H-dibenzo[a,j]xanthenes Using an Efficient Polymer-Supported Catalyst

作者：Naidu Kalla Reddi Mohan; Krishna Balam Satheesh; Kumar Mungara Anil; Arulselvan Palanisamy; Khalivulla Shaik Ibrahim; Lasekan Ola^*

来源：Molecules, 2012, 17(6): 7543-7555.

DOI：10.3390/molecules17067543

• aryl aldehydes
• 2-naphthol
• PEG-OSO3H
• neat reaction
• xanthenes
• tobacco mosaic virus

Polyethyleneglycol bound sulfonic acid (PEG-OSO3H), a chlorosulphonic acid-modified polyethylene glycol was successfully used as an efficient and eco-friendly polymeric catalyst in the synthesis of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes obtained from the reaction of 2-naphthol and carbonyl compounds under solvent-free conditions with short reaction times and excellent yields. The biological properties of these synthesized title compounds revealed that compounds 3b, 3c, 3f and 3i showed highly significant anti-viral activity against tobacco mosaic virus.

• 出版日期2012-6