Mitochondrial permeability transitions: how many doors to the house?

作者：Zoratti M^*; Szabo D; De Marchi U

来源：Biochimica et Biophysica Acta-Bioenergetics, 2005, 1706(1-2): 40-52.

DOI：10.1016/j.bbabio.2004.10.006

• permeability transition
• adenine nucleotide transporter
• Bax
• cyclosporin A
• protein import
• mitochondria

The inner mitochondrial membrane is famously impermeable to solutes not provided with a specific carrier. When this impermeability is lost, either in a developmental context or under stress, the consequences for the cell can be far-reaching. Permeabilization of isolated mitochondria, studied since the early days of the field, is often discussed as if it were a biochemically well-defined phenomenon, occurring by a unique mechanism. On the contrary, evidence has been accumulating that it may be the common outcome of several distinct processes, involving different proteins or protein complexes, depending on circumstances. A clear definition of this putative variety is a prerequisite for an understanding of mitochondrial permeabilization within cells, of its roles in the life of organisms, and of the possibilities for pharmacological intervention.

• 出版日期2005-1-7