A new potential radiosensitizer- multi-walled carbon nanotubes modified by ammonium persulfate

作者：Yang Jian She^*; Jing Xigang; Li Wen Jian; Hu Xiang Kai; Wei Wei; Wang Zhuan Zi

来源：Gene Therapy and Molecular Biology, 2008, 12B: 247-252.

• ammonium persulfate
• multi-walled carbon nanotubes

Here we prepare carbon nanotubes modified with ammonium persulfate, very short carbon nanotubes with 50-100 nanometer length was obtained, and the higher Z potential of 52 mV was detected, these supporting the successful modification. HeLa cells were irradiated with gamma rays via adding or absent above functionalized carbon nanotubes (f-WCNTs) into cell culture medium with different concentration and radiation dosage. Confocal microscopy images and fluorescence-labeled DNA detection verified the successfully pure multi-wailed carbon nanotubes (p-WCNTs) and f-WCNTs penetrated into cells. Compared with pure radiation, by MTT test, f-WCNTs induced cell death markedly with about 8.7 times higher than former one under little dose of radiation; meanwhile, no obvious toxicity was observed both in p-WCNTs and f-WCNTs without of radiation exposure. We hypothesized that large amount of hydroxyl and carbonyl organs on the surface of very short f-WCNTs changed into free radicals result from radiations led cell damage. These implied that f-WCNTs could be regarded as a new radiosensitizer.

• 出版日期2008
• 单位西北师范大学; 中国科学院近代物理研究所