Cerebrospinal Fluid Fatty Acid-Binding Protein 3 is Related to Dementia Development in a Population-Based Sample of Older Adult Women Followed for 8 Years

作者：Bjerke Maria; Kern Silke^*; Blennow Kaj; Zetterberg Henrik; Waern Margda; Borjesson Hanson Anne; Ostling Svante; Kern Jurgen; Skoog Ingmar

来源：Journal of Alzheimer's Disease, 2016, 49(3): 733-741.

DOI：10.3233/JAD-150525

• Cerebrospinal fluid
• dementia
• fatty acid binding protein-3
• older women
• population-based
• prospective

Background: Increased fatty acid-binding protein 3 (FABP-3) levels have been reported in neurodegenerative diseases, including Alzheimer's disease (AD). Cerebrospinal fluid (CSF) FABP-3 has therefore been proposed as a putative marker for dementia. Population-based studies examining whether CSF FABP-3 predicts later development of dementia are lacking.
Objective: The aim of this study was to examine CSF levels of FABP-3 in relation to later development of dementia in elderly women and in relation to A beta(42), T-tau, P-tau(181), and CSF: serum albumin ratio.
Methods: 86 non-demented women aged 70-84 years who participated in the Prospective Population Study of Women in Gothenburg, Sweden took part in a lumbar puncture in 1992-93. CSF-FABP-3, A beta(42), T-tau, P-tau(181), and the CSF: serum albumin ratio were measured at baseline. Participants were examined with a neuropsychiatric exam at baseline and at follow-up in 2000. Dementia was diagnosed in accordance with DSM-III-R criteria.
Results: Between 1992 and 2000, 8 women developed dementia (4 AD, 3 vascular dementia, 1 mixed vascular dementia and AD). Higher levels of CSF-FABP-3 at baseline were related to development of dementia (OR 1.36 CI [1.05-1.76] p = 0.022) and the subtype AD (OR 1.38 CI [1.06-1.82), p = 0.019) during follow-up. FABP-3 correlated with CSF T-tau (r = 0.88, p < 0.001), P-tau(181) (r = 0.619, p < 0.001), and CSF: serum albumin ratio (r = 0.233, p = 0.031), but not with A beta(42) (r = -0.08, p = 0.444).
Conclusion: CSF FABP-3 may be an early marker for later development of dementia, probably related to neuronal degeneration, but independent of A beta metabolism.

• 出版日期2016