Systematic review on the surgical treatment for T1 gallbladder cancer

作者：Lee Seung Eun; Jang Jin Young^*; Lim Chang Sup; Kang Mee Joo; Kim Sun Whe

来源：World Journal of Gastroenterology, 2011, 17(2): 174-180.

DOI：10.3748/wjg.v17.i2.174

• Gallbladder
• Cancer
• Cholecystectomy
• Simple
• Extended

AIM: To evaluate the efficacy of simple and extended cholecystectomy for mucosa (ha) or muscularis (T1b) gallbladder (GB) cancer.
METHODS: Original studies on simple and extended cholecystectonny for T1a or T1b GB cancer were searched from MEDLINE (PubMed), Cochrane Library, EMBase, and CancerLit using the search terms of GB, cancer/carcinoma/tumor/neoplasm.
RESULTS: Twenty-nine out of the 2312 potentially relevant publications met the eligibility criteria. Of the 1266 patients with GB cancer included in the publications, 706 (55.8%) and 560 (44.2%) had T1a and T1b GB cancer, respectively. Simple cholecystectomy for Tla and T1b GB cancer was performed in 590 (83.6%) and 375 (67.0%) patients, respectively (P < 0.01). In most series, the treatment of choice was simple cholecystectomy for ha GB cancer patients with a 5-year survival rate of 100%. Lymph node metastasis was detected in 10.9% of the T1b GB cancer patients and in 1.8% of the Tla GB cancer patients, respectively (P < 0.01). Eight patients (1.1%) with T1a GB cancer and 52 patients (9.3%) with T1b GB cancer died of recurrent GB cancer (P < 0.01).
CONCLUSION: Simple cholecystectomy represents the adequate treatment of Tla GB cancer. There is no definite evidence that extended cholecystectomy is advantageous over simple cholecystectomy for T1b GB cancer.

• 出版日期2011-1-14