Non-invasive Predictors of Human Cortical Bone Mechanical Properties: T-2-Discriminated H-1 NMR Compared with High Resolution X-ray

作者：Horch R Adam^*; Gochberg Daniel F; Nyman Jeffry S; Does Mark D

来源：PLos One, 2011, 6(1): e16359.

DOI：10.1371/journal.pone.0016359

Recent advancements in magnetic resonance imaging (MRI) have enabled clinical imaging of human cortical bone, providing a potentially powerful new means for assessing bone health with molecular-scale sensitivities unavailable to conventional X-ray-based diagnostics. To this end, H-1 nuclear magnetic resonance (NMR) and high-resolution X-ray signals from human cortical bone samples were correlated with mechanical properties of bone. Results showed that H-1 NMR signals were better predictors of yield stress, peak stress, and pre-yield toughness than were the X-ray derived signals. These H-1 NMR signals can, in principle, be extracted from clinical MRI, thus offering the potential for improved clinical assessment of fracture risk.

• 出版日期2011-1-21