Lanthanide-based luminescent probes for selective time-gated detection of hydrogen peroxide in water and in living cells

作者：Lippert Alexander R; Gschneidtner Tina; Chang Christopher J^*

来源：Chemical communications, 2010, 46(40): 7510-7512.

DOI：10.1039/c0cc01560a

Lanthanide-based luminescent probes TPR1 and TPR2 were developed for the detection of hydrogen peroxide (H2O2) in living systems. The chemoselective reaction of these boronate-protected probes with H2O2 resulted in an enhanced lanthanide sensitization and a 6-fold increase in luminescent intensity. TPR2 was utilized to measure the endogenous production of H2O2 in RAW 264.7 macrophages using time-gated luminescent spectroscopy.

• 出版日期2010