Amplified nanostructure electrochemical sensor for simultaneous determination of captopril, acetaminophen, tyrosine and hydrochlorothiazide

作者：Karimi Maleh Hassan^*; Ganjali Mohammad R; Norouzi Parviz; Bananezhad Asma

来源：Materials Science & Engineering C-Materials for Biological Applications, 2017, 73: 472-477.

DOI：10.1016/j.msec.2016.12.094

• Captopril
• Acetaminophen
• Tyrosine
• Hydrochlorothiazide, NiO/CNTs nanocomposite

A novel nanomaterial-based voltammetric sensor has been developed for use a highly sensitive tool for the simultaneous determination of captopril (CA), acetaminophen (AC), tyrosine (TV) and hydrochlorothiazide (HCTZ). The device is based on the application of NiO/CNTs and (2-(3,4-dihydroxyphenethypisoindoline-1,3-dione) (DPID) to modify carbon paste electrodes. The NiO/CNTs nanocomposite was synthesized through a direct chemical precipitation approach and was characterized with X-ray powder diffraction (XRD), and scanning electron microscopy (SEM). The NiO/CNTs/DPID/CPEs were found to facilitate the analysis of CA, AC, TV and HCTZ in the concentration ranges of 0.07-200.0, 0.8-550.0, 5.0-750.0 and 10.0-600.0 mu M with the respective detection limits of 9.0 nM, 03 mu M, 1.0 mu M and 5.0 mu M. The developed NiO/CNTs/DPID/CPEs were used for the determination of the mentioned analytes in pharmaceutical and biological real samples.

• 出版日期2017-4-1