Analgesic effect of topical oral capsaicin gel in burning mouth syndrome

作者：Jorgensen Mette Rose^*; Pedersen Anne Marie Lynge

来源：Acta Odontologica Scandinavica, 2017, 75(2): 130-136.

DOI：10.1080/00016357.2016.1269191

• Glossodynia
• local anesthetics
• neuropathic

Objective: To investigate the effectiveness of repeated topical application of oral capsaicin gel in two different concentrations for relief of burning/stinging sensations in patients with burning mouth syndrome (BMS).Material and methods: This randomized double-blind cross-over study included 22 female patients with BMS. The patients were randomized for topical application of either 0.01% or 0.025% oral capsaicin gel on the dorsal part of tongue three times daily for 14 days, followed by 14 days wash-out period, and finally treatment with the other concentration of oral gel three times daily for 14 days. A visual analogue scale (VAS) was used to assess the severity of pain five times during the intervention period.Results: 18 patients completed the intervention. Their VAS score at baseline was 5.50.6cm (mean +/- SD). Treatment with the two concentrations of capsaicin gels significantly improved the burning/stinging symptoms assessed on VAS compared with baseline (p=0.002). There was no statistically significant difference between the two concentrations of the gels on relieving symptoms. Four patients dropped out during the intervention period due to gastrointestinal side-effects.Conclusions: Topical capsaicin might be an alternative for the short-term treatment of BMS. However, further studies are needed to investigate especially the gastro-intestinal side-effects which may limit its long-term use.

• 出版日期2017-3