An Efficient Route to Acyclic C-Nucleosides and Fused-Ring Analogues of Uridine from exo-Glycals

作者：Enderlin Gerald; Taillefumier Claude; Didierjean Claude; Chapleur Yves^*

来源：Journal of Organic Chemistry, 2009, 74(21): 8388-8391.

DOI：10.1021/jo901604w

beta-Amino esters prepared from activated exo-glycals are transformed into acyclic C-nucleoside with a C-4-substituted uracil derivative that can be cyclized under Mitsututed conditions to provide it new Family of fused-ring analogues of uridine nucleoside in which the N-1 nitrogen atom is embedded in an amino sugar ring. An analogue of uridine of D-1 ibo configuration is prepared.

• 出版日期2009-11-6