A highly sensitive turn-on fluorescent chemosensor for recognition of Zn2+ and Hg2+ and applications

作者：Tang, Xu; Han, Juan^*; Wang, Yun; Bao, Xu; Ni, Liang^*; Wang, Lei; Li, Longhua

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2017, 184: 177-183.

DOI：10.1016/j.saa.2017.05.011

• Chemosensor
• Fluorescence
• Metal ions
• DFT calculations
• Cell imaging

A fluorescence probe has been designed and synthesized, and applied with a combined theoretical and experimental study. Research suggests that the probe can be used to sense Zn2+ and Hg2+ through selective turn-on fluorescence responses in the aqueous HEPES buffer (0.05M, pH = 7.4). The limit of detection (LOD) were determined as 1.46 x 10(-7)M (Zn2+) and 2.50 x 10(-7)M (Hg2+). Moreover, based on DFT, the geometry optimizations of probe 1, [1-Hg2+] complex and [1-Zn2+] complex were carried out using the Gaussian 09 program, in which the B3LYP function was used. The electronic properties of free probe 1 and the metal complexes were studied based on the Natural Bond Orbital (NBO) analyses. The probe 1 has also been successfully applied to detection of Zn2+ and Hg2+ in living cells.

• 出版日期2017-9-5
• 单位江苏大学