Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma

作者：Witt Hendrik; Mack Stephen C; Ryzhova Marina; Bender Sebastian; Sill Martin; Isserlin Ruth; Benner Axel; Hielscher Thomas; Milde Till; Remke Marc; Jones David T W; Northcott Paul A; Garzia Livia; Bertrand Kelsey C; Wittmann Andrea; Yao Yuan; Roberts Stephen S; Massimi Luca; Van Meter Tim; Weiss William A; Gupta Nalin; Grajkowska Wiesia; Lach Boleslaw; Cho Yoon Jae; von Deimling Andreas; Kulozik Andreas E; Witt Olaf; Bader Gary D; Hawkins Cynthia E

来源：Cancer Cell, 2011, 20(2): 143-157.

DOI：10.1016/j.ccr.2011.07.007

Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) ependymomas. Group A patients are younger, have laterally located tumors with a balanced genome, and are much more likely to exhibit recurrence, metastasis at recurrence, and death compared with Group B patients. Identification and optimization of immunohistochennical (IHC) markers for PF ependymoma subgroups allowed validation of our findings on a third independent cohort, using a human ependymonna tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependymoma patients.

• 出版日期2011-8-16