Multivitamin supplementation improves nutritional status and bone quality in aged care residents

作者：Grieger J A; Nowson C A^*; Jarman H F; Malon R; Ackland L M

来源：European Journal of Clinical Nutrition, 2009, 63(4): 558-565.

DOI：10.1038/sj.ejcn.1602963

• multivitamin
• residential care
• 25(OH)D
• heel ultrasound

Objectives: To assess the effectiveness of a multivitamin (MV) tablet on nutritional status, quantitative heel ultrasound (QUS), mobility, muscle strength and falls. The design comprised two groups matched on mobility levels, randomized to receive a daily MV or placebo (P) tablet for 6 months. The setting was an Australian residential care facility.
Subjects: A total of 92 aged care residents. Serum micronutrients, body weight, QUS, rate of falls, hand grip strength, and the timed up and go test were assessed at baseline and 6 months.
Results: A total of 49 participants consumed a MV and 43, a matched P for 6 months. There was a greater increase in the MV vs P group for serum 25(OH)D (mean difference +/- standard error, 33.4 +/- 2.6 nmoll(-1)), folate (13.4 +/- 2.8 nmoll(-1)), and vitamin B12 (178.0 +/- 40.3 pmoll(-1)) (all P < 0.001). Adequate 25(OH)D concentrations (>= 50 nmoll(-1)) were found among 77% of participants in the MV group vs 10% taking P (P < 0.001). Adjusting for baseline levels, the increase in QUS was greater in the MV vs P group (3.0 +/- 2.0 dB MHz(-1) vs -2.9 +/- 2.1 dB MHz(-1), respectively, P = 0.041). There was a trend towards a 63% lower mean number of falls in the MV vs P group (0.3 +/- 0.1 falls vs 0.8 +/- 0.3 falls, P = 0.078).
Conclusions: MV supplementation raised serum vitamin B12 and folate concentrations and increased serum 25(OH)D, which was accompanied by an apparent positive effect on bone density. We also found a trend towards a reduction in falls and this could contribute to a reduction in fractures.

• 出版日期2009-4
• 单位迪肯大学