Assessment of Cognitive Function Before and After Surgery for Posterior Cranial Fossa Lesions Using Computerized and Conventional Tests

作者：Ichimura Shinya^*; Ohira Takayuki; Kobayashi Masahito; Kano Tadashige; Akiyama Takekazu; Orii Maaya; Fukunaga Atsushi; Kawase Takeshi

来源：Neurologia Medico-Chirurgica, 2010, 50(6): 441-448.

• neuropsychological evaluation
• higher brain function
• computerized test
• before and after surgery
• skull base surgery

Cognitive function has not been well studied after neurosurgery for posterior fossa lesions despite its potential importance in determining surgical indications and approaches. The present study evaluated changes in cognitive functions after posterior fossa surgery to detect any differences between the middle cranial fossa and lateral suboccipital approaches in 50 patients with posterior fossa lesions such as tumors and vascular diseases. Twenty-five patients underwent surgery via the middle fossa and 25 via the lateral suboccipital approaches. Computerized test battery (CogState(TM)) and conventional neuropsychological tests (serial seven-word learning test and mini-mental state examination) were examined before, 1 month after, and 3 months after surgery. All scores of the neuropsychological tests remained within normal limits after surgery. However, the scores of one computerized test battery and serial seven-word learning tests decreased significantly 1 month after surgery and recovered within 3 months, indicating temporary deterioration of short-term memory in the middle fossa group. The computerized tests detected significantly larger numbers of patients with worsened results than the conventional tests. The middle fossa approach and operation time showed correlations with the postoperative neuropsychological declines. The computerized tests could be performed easily and were beneficial for detecting subtle changes of the cognitive function after surgery. Cognitive function, especially short-term memory, may decline temporarily with the middle fosse approach and long operation time.

• 出版日期2010-6