A Red Fluorescence Two-photon Absorption Probe for Sensitive Imaging of Live Mitochondria

作者：Tominaga Makoto; Mochida Shuhei; Sugihara Hiroyuki; Satomi Koichiro; Moritomo Hiroki; Fuji Akinari; Tomoyuki Arina; Suzuki Yasutaka^*; Kawamata Jun

来源：Chemistry Letters, 2014, 43(9): 1490-1492.

DOI：10.1246/cl.140447

We synthesized two-photon absorption probes based on naphthalene and anthracene: 1,1%26apos;-dimethyl-4,4%26apos;-(2,6-naphthylenedi-2,1-ethenediyl)dipyridinium diiodide (NP) and 1,1%26apos;-dimethyl-4,4%26apos;-(2,6-anthrylenedi-2,1-ethenediyl)dipyridinium diiodide (AC). These two probes were successfully accumulated in mitochondria with different fluorescence colors: yellow (NP) and red (AC). Two-photon absorption cross sections (a(2)) were 712 and 685 GM (1 GM = 10(-50) cm(4) s photon(-1) molecule(-1)), respectively. These values are nine times larger than the sigma((2)) of the commercially available mitochondria-selective probe with efficient two-photon absorption property (rhodamine 123).

• 出版日期2014-9-5