Association study of polymorphisms in the cyclooxygenase-2 gene and Alzheimer's disease risk in Chinese

作者：Tang, Wenlu; He, Meixia; Yang, Bo; Wei, Kankan; Yin, Ming; Zhang, Lirong^*

来源：Neurological Sciences, 2013, 34(5): 695-699.

DOI：10.1007/s10072-012-1115-9

• Alzheimer's disease
• Cyclooxygenase-2
• Single nucleotide polymorphisms
• Susceptibility

To determine if polymorphisms (-765G/C, -1195G/A and 8473T/C) of the cyclooxygenase-2 (COX2) gene can be associated with Alzheimer disease (AD). The frequency of the polymorphisms was determined in 244 cases and 226 controls. The results revealed that the distributions of COX-2 -765G/C and 8473T/C polymorphisms were statistically not significant between AD cases and controls. The genotype distributions and allele frequencies of COX-2 -1195G/A polymorphism in the cases were statistically significantly different from the controls (P < 0.05). The A/A distribution and A allele frequency were significantly lower in the AD group. COX-2 -1195AA carriers showed a one-third lower risk of developing AD as compared to those with -1195GG and GA genotypes (OR = 0.3, 95 % CI 0.194-0.465, P = 0.000). This study suggested that -1195G/A polymorphism of the COX-2 gene is associated with the risk of AD, and the A allele represents a protective factor in patients with AD.

• 出版日期2013-5
• 单位郑州大学; 上海交通大学; 复旦大学