Neonatal IGF-1/IGFBP-1 axis and retinopathy of prematurity are associated with increased blood pressure in preterm children

作者：Kistner Anna^*; Sigurdsson Jon; Niklasson Aimon; Lofqvist Chatarina; Hall Kerstin; Hellstrom Ann

来源：Acta Paediatrica, 2014, 103(2): 149-156.

DOI：10.1111/apa.12478

• Catch-up growth
• Diastolic blood pressure
• IGF-1
• IGFBP-1
• Preterm children
• Retinopathy of prematurity

AimPreterm children are at risk of developing increased blood pressure (BP). We evaluated possible associations between BP, early insulin-like growth factor-1 (IGF-1) and IGF-binding protein-1 (IGFBP-1) levels and retinopathy of prematurity (ROP) in preterm children.
MethodsThe study included 32 infants: median gestational age 28.1weeks (range 24.6-31.3) and birthweight standard deviation scores (SDS) (SD) 1.02.7. IGF-1 and IGFBP-1 at postnatal weeks 32.6-34.6 and ROP stages were established after birth. BP was measured at the age of 4years. The ratio (IGF-1)(2)/IGFBP-1 was created to investigate the influence of both IGF-1 and IGFBP-1 to later BP.
ResultsDiastolic BP correlated with IGFBP-1, inversely correlated with IGF-1 and IGF-1(2)/IGFBP-1 (r=-0.71, p<0.0001) and positively correlated with catch-up growth velocity from lowest weight SDS to age 36.5weeks (r=0.48, p<0.01), independent of gestational age. Children with moderate-to-severe ROP as neonates had higher mean arterial BP [78 (+/- 95%CI 74-83) vs 71 (+/- 95%CI 68-75) mm Hg, p<0.05] adjusted for gestational age and birthweight SDS compared to children diagnosed with no to mild ROP.
ConclusionLow neonatal IGF-1(2)/IGFBP-1 and severe ROP were associated with higher BP in 4-year-old children born very preterm and may thus predict future cardiovascular morbidity.

• 出版日期2014-2