An in vitro cellular system modelling progressive human adipose-derived stem cell aging

作者：Shi, Yanghua; Wang, Lian; Li, Yichang; Xu, Congdi; Shao, Xiaowen; Cheng, Zhongping; Jiang, Mei; Cheng, Jiajing; Xu, Jun; Song, Jianxing^*; Wang, Xiuli^*; Gao, Zhengliang^*

来源：Science Bulletin, 2018, 63(5): 272-274.

DOI：10.1016/j.scib.2018.01.005

<正>Adipose-derived stem cells(ADSCs)assume essential roles in tissue homeostasis and aging and have been explored as regenerative therapies for a broad range of diseases including physiological and pathological aging[1].These multipotent cells are plastic,capable to differentiate and transdifferentiate to a range of cell types[2].With aging,diseases and in vitro passing,ADSCs decline and undergo cellular senescence[3].For therapies,typically cells from young adults before 5–8 passages should be used,posing major

• 出版日期2018-3-15
• 单位中国人民解放军第二军医大学; 同济大学